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French fries, pizza and Co.: A single high-fat meal can affect your metabolism
You don't necessarily have to grab fries, cheeseburgers, and pizza every day to increase your risk of diabetes. According to a new study, a single high-fat meal is enough to provoke insulin resistance and increase the fat content in the liver.
Saturated fats damage health
Diet has a big impact on our health. For example, experts advise against the regular consumption of saturated fats, as these affect general life expectancy. The consumption of such fats is often associated with the worldwide spread of obesity, obesity and type 2 diabetes. Researchers have now found that you don't have to consume much of it to harm your health. A single high-fat meal can affect your metabolism.
Study provides information on the earliest changes in liver metabolism
Scientists at the German Diabetes Center (DDZ) and the Helmholtz Center in Munich have found that the single intake of a large amount of palm oil reduces the body's sensitivity to insulin and increases fat storage and changes in the liver's energy metabolism.
As stated in a statement by the Helmholtz Center, the study results provide information about the earliest changes in liver metabolism that can lead to fatty liver diseases in obesity and type 2 diabetes in the long term.
A single high-fat meal can cause insulin resistance
In the journal "Clinical Investigation", the researchers from the German Center for Diabetes Research (DZD), together with Portuguese colleagues, published an investigation into healthy, slim men who randomly drink an aromatized palm oil drink and sometimes a glass of clear water received.
According to the information, the palm oil drink contained a similar amount of saturated fat as two cheeseburgers with bacon and a large portion of french fries or like two salami pizzas.
The experts showed that this single high-fat meal is sufficient to reduce the insulin effect, i.e. to induce insulin resistance and to increase the fat content of the liver.
In addition, changes in the energy balance of the liver could be demonstrated.
The observed metabolic changes are similar to the changes seen in people with type 2 diabetes or non-alcoholic fatty liver disease (NAFLD).
“NAFLD is the most common liver disease in industrialized countries and is associated with obesity, the so-called“ metabolic syndrome ”, and increased risk of type 2 diabetes. In addition, NAFLD can lead to severe liver damage in advanced stages, ”says a statement from the DDZ.
Effects on the liver of healthy people
"It was surprising that a single dose of palm oil in healthy people has such a quick and direct effect on the liver and that the amount of fat administered triggers insulin resistance," said Prof. Dr. Michael Roden, Scientific Director and Board Member at DDZ and DZD.
Experts have warned of the risks of palm oil in food in the past and have indicated that it should be replaced entirely.
Muscles, liver and adipose tissue are affected by palm oil
Thanks to new research methods, the scientists demonstrated that the intake of palm oil affects muscles, liver and adipose tissue in their metabolic activity.
The resulting insulin resistance leads to increased sugar re-formation in the liver and at the same time a reduced sugar intake in the skeletal muscles, a mechanism that increases the blood sugar level in type 2 diabetes and its precursors.
In addition, the insulin resistance of the adipose tissue causes an increased release of fats into the bloodstream, which in turn further promotes insulin resistance.
The increased availability of fat thus leads to an increased workload of the mitochondria, which in the long term can overwhelm these cellular power plants and contribute to the development of liver disease.
The team of scientists suspects that healthy people can easily cope with the immediate effects of high-fat food on their metabolism, depending on the predisposition of the genes. However, the long-term consequences for regular eaters of such high-fat meals could be problematic. (ad)